What do you do when somebody is hurting?

I'm worried about my sweetie. Things are not going well morale-wise. She's fed up of being sick, which is perfectly understandable, and she's always tired because her cough is keeping her up at night. I wouldn't be overly worried if it was only that though, because those things will get better as she heals.

What *is* worrying me though is that she seems very… fragile right now, for lack of a better word. I don't know how to help.